New method for diagnosing esophageal cancer in low-income countries
Point-of-Care Diagnosis of Esophageal Cancer in LMICs
This study is testing a simple and affordable way to help find esophageal cancer early by using a swallowable sponge that collects samples, making it easier for people in low- and middle-income countries to get checked without needing fancy equipment or special training.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10843258 on NIH RePORTER |
What this research studies
This research aims to develop a cost-effective and non-invasive method for diagnosing esophageal cancer, particularly squamous cell carcinoma, in low- and middle-income countries (LMICs). It utilizes a swallowable sponge device that collects esophageal samples, which are then analyzed using a portable magnetofluidic chip for DNA methylation markers. This approach is designed to be performed in remote areas without the need for extensive medical training or advanced equipment, making it accessible for high-risk patients. By improving early detection, the research seeks to enhance treatment options and outcomes for patients in these regions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in low- and middle-income countries who are at high risk for esophageal cancer.
Not a fit: Patients with esophageal cancer who are already diagnosed and receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve early detection and treatment of esophageal cancer in underserved populations.
How similar studies have performed: Other research has shown promise in using innovative diagnostic methods for cancer detection in resource-limited settings, indicating potential success for this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Meltzer, Stephen J — Johns Hopkins University
- Study coordinator: Meltzer, Stephen J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.