New method for detailed 3D imaging of brain synapses
Official title: Multiplex Magnify Protocol and Kit for High Plex, Superresolution 3D Synaptic Imaging and Analysis in Neuroscience
Funded at Magnify Biosciences INC. · NIH-11008538 · Data updated 2026-11-12
This study is working on a new way to take clearer 3D pictures of tiny connections in the brain, which will help scientists learn more about how the brain works and what goes wrong in diseases, making it easier for researchers to explore different types of brain tissue.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magnify Biosciences INC. NIH-funded |
| Lab location | 1 site (Sewickley, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $457,026 |
| NIH project number | 1R43MH138930-01 |
| Project ID | NIH-11008538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that affect synaptic function, such as Alzheimer's disease or autism spectrum disorders.
✕Less likely to help
Patients with conditions unrelated to synaptic dysfunction or those who do not have access to advanced imaging facilities may not benefit from this research.
What this research studies
This research focuses on developing a new protocol and kit that enhances the imaging of synapses in the brain, which are crucial for understanding brain function and diseases. By utilizing a technique called Expansion Microscopy, the project aims to significantly improve the resolution of 3D images of synaptic proteins, allowing for better mapping of their organization. This method is designed to be efficient and compatible with various tissue types, making it a versatile tool for neuroscientists. The goal is to create a prototype that can be widely used in neuroscience research to advance our understanding of brain anatomy and function.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain diseases and developing targeted therapies.
How similar studies have gone: Previous research has shown promise with similar imaging techniques, indicating potential for success in this novel approach.
Where this research is happening
-
Magnify Biosciences INC.
Sewickley, United States Active
Researchers
- Principal investigator: Klimas, Aleksandra — Magnify Biosciences INC.
- Study coordinator: Klimas, Aleksandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.