New medicines to help teeth erupt properly
Pharmacological rescue of tooth eruption disorders
This project looks for new medicines to help teeth come in correctly, especially for children with certain conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11113978 on NIH RePORTER |
What this research studies
Tooth eruption problems, like when teeth don't come in at all, can make it hard to chew and affect quality of life. These issues are common, especially in children with rare genetic conditions or those taking certain medications called bisphosphonates. Current treatments often don't work well for these specific problems. This research aims to find new drug treatments that can help teeth erupt by targeting specific signals within the cells that guide tooth development.
Who could benefit from this research
Good fit: This research is relevant for patients, especially children, who experience tooth eruption disorders, including those with primary failure of tooth eruption (PFE) or bisphosphonate-induced tooth eruption arrest.
Not a fit: Patients without tooth eruption disorders or those whose conditions respond well to traditional orthodontic treatments may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new drug therapies that help teeth erupt properly, improving chewing ability and overall quality of life for affected patients.
How similar studies have performed: This project explores a novel therapeutic strategy using small molecule SIK inhibitors to enhance tooth eruption, building on existing knowledge of PTH1R signaling in bone.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Ono, Wanida — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Ono, Wanida
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.