New Medicines for Alzheimer's Disease
Novel Inhibitors of Lysine Methyltransferases G9a and GLP for the Treatment of Alzheimer's Disease
This research looks for new small molecule medicines that might help people with Alzheimer's disease by targeting specific proteins in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11118839 on NIH RePORTER |
What this research studies
Researchers are working to find and improve new drug candidates that could treat Alzheimer's disease. They believe that by blocking certain proteins, called G9a and GLP, they can help correct brain abnormalities linked to the condition. The team will test these new medicines in laboratory models to see how well they work and how safe they are. The goal is to develop a promising drug candidate that can eventually be tested in people.
Who could benefit from this research
Good fit: This foundational research is not yet recruiting patients, but future clinical trials stemming from this work would likely seek individuals diagnosed with Alzheimer's disease.
Not a fit: Patients without Alzheimer's disease would not directly benefit from this specific therapeutic approach.
Why it matters
Potential benefit: If successful, this work could lead to a new type of medicine that slows or stops the progression of Alzheimer's disease.
How similar studies have performed: This approach targets specific proteins linked to Alzheimer's disease, representing a novel strategy that builds on recent scientific discoveries.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Jin, Jian — Icahn School of Medicine at Mount Sinai
- Study coordinator: Jin, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.