New materials that release carbon monoxide for health
Official title: CO Releasing Organic Polymers for Biomedical Applications
Funded at University of Denver (Colorado Seminary) · NIH-11116880 · Data updated 2026-11-12
This project is creating new materials that can safely deliver carbon monoxide to help treat conditions like heart disease and inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $363,408 |
| NIH project number | 5R35GM147473-04 |
| Project ID | NIH-11116880 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cardiovascular diseases, chronic inflammation, or those undergoing organ transplantation might eventually benefit from therapies developed using these new materials.
✕Less likely to help
Patients whose conditions are not related to the therapeutic effects of carbon monoxide, such as inflammation, cardiovascular disease, or organ transplant rejection, may not directly benefit from this specific research.
What this research studies
Carbon monoxide, or CO, is naturally found in our bodies and plays a role in our health, even showing promise as a treatment for issues like inflammation and heart problems. However, using CO directly as a medicine is tricky because it's a gas and can be toxic in large amounts. Researchers are developing special materials called CO Releasing Molecules (CORMs) that can release CO in a controlled way. This particular work focuses on creating new, safer organic polymer-based CORMs to improve how CO can be used therapeutically.
Why it matters
Potential benefit: If successful, this work could lead to new and safer ways to deliver carbon monoxide as a treatment for cardiovascular diseases, inflammation, and to help prevent organ transplant rejection.
How similar studies have gone: While existing CO Releasing Molecules (CORMs) have been developed, this research aims to create a novel class of organic polymer-based CORMs to address the limitations of current metal-based approaches.
Where this research is happening
-
University of Denver (Colorado Seminary)
Denver, United States Active
Researchers
- Principal investigator: Worrell, Brady — University of Denver (Colorado Seminary)
- Study coordinator: Worrell, Brady
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.