New long-lasting treatments for eye diseases causing blindness
Official title: Long-acting formulations of griseofulvin for ocular neovascularization therapy
Funded at Purdue University · NIH-11172603 · Data updated 2026-11-12
This study is working on a new way to use the anti-fungal medicine griseofulvin to help treat eye conditions that can cause vision loss, making it easier and less frequent for patients to get their treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | July 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $649,794 |
| NIH project number | 5R01EY035159-03 |
| Project ID | NIH-11172603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from ocular neovascularization due to conditions such as age-related macular degeneration or proliferative diabetic retinopathy.
✕Less likely to help
Patients with non-neovascular eye conditions or those who do not respond to anti-angiogenic therapies may not benefit from this research.
What this research studies
This research focuses on developing a long-acting formulation of the anti-fungal drug griseofulvin to treat ocular neovascularization, a condition that can lead to blindness. The approach involves repurposing griseofulvin, which has shown promise in blocking the growth of abnormal blood vessels in the eye. By creating a sustained-release formulation, the goal is to reduce the frequency of injections needed for treatment, addressing issues like resistance to current therapies and high costs. Patients may benefit from a more effective and convenient treatment option for conditions like age-related macular degeneration and diabetic retinopathy.
Why it matters
Potential benefit: If successful, this research could provide patients with a more effective and less burdensome treatment for eye diseases that cause vision loss.
How similar studies have gone: Previous research has shown promise in repurposing existing drugs for similar conditions, indicating potential success for this approach.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Yeo, Yoon — Purdue University
- Study coordinator: Yeo, Yoon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.