New immune protein made from non-coding RNA
In vivo functional characterization of a novel protein encoded by a lncRNA
['FUNDING_R03'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-11291322
Researchers want to find out whether a newly discovered protein made from a non-coding RNA changes how immune cells behave in severe inflammation like sepsis.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-11291322 on ClinicalTrials.gov |
What this research studies
From a patient point of view, the team has found a mysterious RNA that is active in defensive immune cells and may also make a small secreted protein. They will use lab experiments and live animal models to see how this protein affects macrophages and inflammatory damage. The researchers will turn the protein on or off and measure immune responses, tissues, and survival in acute inflammation models. Their work aims to reveal whether this molecule could become a target for treating harmful inflammation.
Who could benefit from this research
Good fit: People with severe acute inflammatory conditions such as sepsis or other disorders driven by overactive innate immune cells would be the most likely group to benefit from future therapies based on this work.
Not a fit: People with medical problems unrelated to innate immune–driven inflammation or who need treatments unrelated to macrophage activity are unlikely to benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could point to a new target for therapies that reduce dangerous inflammation in conditions such as septic shock.
How similar studies have performed: Prior research has shown some non-coding RNAs can produce functional small proteins that affect cells, but this particular protein is newly identified and has not yet been tested in patients.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KREMENTSOV, DIMITRY N — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: KREMENTSOV, DIMITRY N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.