New imaging tools to identify senescent cells in arthritis
Cellular Senescence Network: New Imaging Tools for Arthritis Imaging
This study is working on a new way to see and track harmful cells in the joints of people with arthritis, which could help doctors choose the best treatments to reduce inflammation and improve healing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10919233 on NIH RePORTER |
What this research studies
This research focuses on developing advanced imaging techniques to identify and map senescent cells in the joints of patients with arthritis. Senescent cells contribute to chronic inflammation and joint damage, and the study aims to create a new imaging biomarker that can help visualize these cells in musculoskeletal tissues. By using a novel compound that targets senescent cells, the research seeks to improve patient selection for senolytic therapies, which aim to clear these harmful cells and promote healing. This approach could lead to better monitoring of treatment responses and ultimately improve outcomes for patients with arthritis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis or osteoarthritis who may have a high presence of senescent cells in their joints.
Not a fit: Patients without arthritis or those whose condition is not related to cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for arthritis by identifying patients who would benefit from therapies that target senescent cells.
How similar studies have performed: Other research has shown promising results with similar imaging approaches and senolytic therapies, indicating potential for success in this novel application.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Daldrup-Link, Heike Elizabeth — Stanford University
- Study coordinator: Daldrup-Link, Heike Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.