New imaging technologies to analyze brain function related to calcineurin
Emerging imaging technologies for automated analyses of calcineurin-dependent brain function
This study is exploring how a key enzyme called calcineurin impacts brain function, especially in Alzheimer's disease, using a special imaging system to observe zebrafish larvae, which could help us find new ways to understand and treat related brain conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10655509 on NIH RePORTER |
What this research studies
This research focuses on understanding how calcineurin, a critical enzyme, affects brain function, particularly in conditions like Alzheimer's disease. The team has developed a unique imaging system that allows for automated analysis of behavior in zebrafish larvae, which can reveal subtle changes in brain activity. By optimizing this technology, the researchers aim to uncover new insights into neural dysfunction and potential treatments. Patients may benefit from advancements in understanding and treating conditions linked to calcineurin signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with conditions unrelated to calcineurin signaling or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Alzheimer's disease and other related conditions.
How similar studies have performed: Other research has shown promise in using advanced imaging technologies to study brain function, suggesting potential for success in this novel approach.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Creton, Robbert J — Brown University
- Study coordinator: Creton, Robbert J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.