New imaging technique to visualize inflammation in coronary artery disease
Clinical translation of targeted intracoronary imaging for inflammatory activity
This study is looking at a new imaging tool called LUM015 that helps doctors see and measure inflammation in the arteries of people with coronary artery disease, which could lead to more personalized and effective treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10877138 on NIH RePORTER |
What this research studies
This research investigates a novel imaging agent called LUM015, which can help visualize and quantify inflammation in coronary artery disease (CAD). By using a specialized imaging system, the study aims to assess the inflammatory activity in atherosclerotic plaques during procedures like carotid endarterectomy. The approach combines optical coherence tomography with near-infrared fluorescence imaging to provide detailed insights into plaque characteristics and their potential risks. This could lead to better management of CAD by allowing for targeted treatments based on the inflammatory status of the plaques.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing procedures for coronary artery disease, particularly those with atherosclerosis.
Not a fit: Patients without coronary artery disease or those not undergoing relevant procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients with coronary artery disease.
How similar studies have performed: Other research has shown promise in using imaging techniques for assessing inflammation in cardiovascular diseases, making this approach a potentially valuable advancement.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Tearney, Guillermo J — Massachusetts General Hospital
- Study coordinator: Tearney, Guillermo J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.