New imaging technique to monitor blood flow and metabolism in the brain of small animals
Official title: High-density optical tomography of cerebral blood flow and metabolism in small animals
Funded at Biopticstechnology, LLC · NIH-10461939 · Data updated 2026-11-12
This study is testing a new way to take pictures of blood flow and oxygen use in the brains of small animals like mice and rats, which could help us learn more about brain health and recovery after strokes, ultimately leading to better treatments for neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biopticstechnology, LLC NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $346,915 |
| NIH project number | 5R41NS122722-02 |
| Project ID | NIH-10461939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals with neurological disorders or conditions affecting cerebral blood flow.
✕Less likely to help
Patients with conditions unrelated to cerebral blood flow or brain metabolism may not receive any benefit from this research.
What this research studies
This research focuses on developing a novel imaging technology to monitor cerebral blood flow (CBF) and metabolism in small animals like mice and rats. The innovative method, called speckle contrast diffuse correlation tomography (scDCT), allows for noninvasive and continuous imaging, which is crucial for understanding brain health and recovery after conditions like stroke. By providing high-resolution images of blood flow and oxygen consumption in the brain, this research aims to improve our understanding of neurological disorders and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment strategies for brain-related conditions in humans.
How similar studies have gone: While this approach is innovative, similar imaging techniques have shown promise in other areas of biomedical research, indicating potential for success.
Where this research is happening
-
Biopticstechnology, LLC
Lexington, United States Active
Researchers
- Principal investigator: Yu, Guoqiang — Biopticstechnology, LLC
- Study coordinator: Yu, Guoqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.