New imaging technique for studying tissue function using x-rays
Official title: Cherenkov Excited Luminescence Metabolic Sensing (CELMS)
Funded at Dartmouth College · NIH-11319452 · Data updated 2026-11-12
This study is testing a new imaging method that uses special x-rays to help doctors see how well your tissues are working, which could lead to better diagnoses and understanding of your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | December 12, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $210,947 |
| NIH project number | 7R01EB033877-03 |
| Project ID | NIH-11319452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may require advanced imaging for conditions related to tissue metabolism.
✕Less likely to help
Patients who are under 21 years old or those who do not require advanced imaging techniques may not benefit from this research.
What this research studies
This research focuses on developing a novel imaging technique called Cherenkov Excited Luminescence Metabolic Sensing (CELMS), which utilizes high-energy x-rays from a linear accelerator to excite optical molecular probes deep within tissues. By employing this method, researchers aim to achieve high-resolution imaging of small molecule tracers that indicate tissue function in living organisms. The technique allows for imaging through several centimeters of tissue while maintaining high sensitivity and spatial resolution, making it a significant advancement in molecular imaging. Patients may benefit from improved diagnostic capabilities and better understanding of tissue metabolism and function.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and sensitive imaging techniques for diagnosing and monitoring various medical conditions.
How similar studies have gone: This approach is innovative and represents a novel advancement in molecular imaging, with no direct precedents in similar methodologies.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Pogue, Brian William — Dartmouth College
- Study coordinator: Pogue, Brian William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.