New imaging technique for studying cells and tissues in detail
Official title: Realizing BRAVE-EM for Nanoscale Multicolor Imaging in Biology: Biological Real-space Absorption Visualization by photoEmission Electron Microscopy
Funded at University of Chicago · NIH-10937282 · Data updated 2026-11-12
This study is testing a new imaging technique called BRAVE-EM that helps scientists see tiny details of proteins and molecules in cells, which could improve our understanding of diseases like cancer and how they develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $291,224 |
| NIH project number | 1R35GM154855-01 |
| Project ID | NIH-10937282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic cancer or related conditions, particularly those interested in the biological mechanisms of their disease.
✕Less likely to help
Patients with non-cancerous conditions or those not involved in the study of cellular imaging may not benefit from this research.
What this research studies
This research focuses on developing a novel imaging technique called BRAVE-EM, which combines the strengths of optical light microscopy and electron microscopy. By using this advanced method, researchers aim to visualize specific proteins and molecules within cells and tissues at an unprecedented resolution of less than 20 nanometers. This could significantly enhance our understanding of diseases, particularly cancer, by allowing for detailed observations of how variations in protein expression affect tumor behavior and progression. The approach leverages recent technological advancements to improve the imaging of biological samples, which is crucial for both basic research and potential therapeutic applications.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cancer biology and improving treatment strategies.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques for biological studies, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: King, Sarah Bailey — University of Chicago
- Study coordinator: King, Sarah Bailey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.