New imaging agents for detecting Tau protein in Alzheimer's disease
Official title: Novel Tau-Targeted Radiohalogenated Agents for Alzheimer's Disease
Funded at University of California-Irvine · NIH-11031984 · Data updated 2026-11-12
This study is working on new imaging agents that can help doctors see Tau proteins in the brains of people with Alzheimer's disease, which could lead to better ways to diagnose the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | February 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $641,140 |
| NIH project number | 5R01AG077700-02 |
| Project ID | NIH-11031984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who are undergoing imaging studies.
✕Less likely to help
Patients with other forms of dementia that do not involve Tau protein aggregation may not benefit from this research.
What this research studies
This research focuses on developing novel radiohalogenated agents that can bind to Tau proteins associated with Alzheimer's disease. By creating and testing these imaging agents, the researchers aim to improve the ability to visualize Tau protein aggregation in the brains of individuals with Alzheimer's and related dementias. The study will utilize advanced imaging techniques such as PET and SPECT to evaluate the effectiveness of these agents in both postmortem human brain samples and in vivo settings. This could lead to better diagnostic tools for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could enhance early diagnosis and monitoring of Alzheimer's disease through improved imaging techniques.
How similar studies have gone: Previous research has shown promise in using imaging agents for detecting Tau proteins, indicating that this approach has potential for success.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Mukherjee, Jogeshwar — University of California-Irvine
- Study coordinator: Mukherjee, Jogeshwar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.