New exercise program for older patients with heart failure

PRIME HRrEF: Novel Exercise for Older Patients with Heart Failure with Reduced Ejection Fraction

NIH-funded research University of Virginia · NIH-10878844

This study is testing a new exercise program made just for older adults with heart failure to help them feel stronger and improve their daily lives through safe and tailored workouts.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Virginia NIH-funded
Lab location1 site (Charlottesville, United States)
Project IDNIH-10878844 on NIH RePORTER

What this research studies

This research investigates a novel exercise program specifically designed for older adults suffering from heart failure with reduced ejection fraction. The program aims to improve physical capacity and quality of life by focusing on tailored aerobic and resistance training that considers the unique challenges faced by this age group. By addressing the limitations of existing exercise guidelines, which are based on younger populations, the research seeks to determine the effectiveness and safety of this approach in real-world settings. Participants will engage in structured exercise sessions that aim to enhance their overall fitness and functional abilities.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with heart failure with reduced ejection fraction.

Not a fit: Patients who are younger than 65 or those without heart failure may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve the physical health and quality of life for older patients with heart failure.

How similar studies have performed: Previous research has shown that tailored exercise programs can lead to meaningful improvements in health outcomes for older adults with heart failure, suggesting that this approach may be effective.

Where this research is happening

Charlottesville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.