New England Addiction Treatment Network
CTN New England Consortium Node
This program explores ways to help people with opioid use disorder stay in treatment and get medication quickly in emergency rooms, ambulances, or clinics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11261050 on NIH RePORTER |
What this research studies
From your perspective, this New England node runs several linked efforts that try different ways to start and keep people on medications for opioid use disorder, including beginning treatment in the emergency department or with EMS, comparing methadone versus buprenorphine in clinic settings, and testing higher versus standard buprenorphine doses. Some parts follow patients remotely to track recovery and retention, while others focus on adolescents exposed to opioids after surgery. Many of the projects use real-world clinic and emergency settings and include randomized or pragmatic designs so findings apply to everyday care. If you join, you might have treatment started for you in the ED or by EMS, be randomly assigned to one of the accepted medication approaches, and share follow-up information by phone or online.
Who could benefit from this research
Good fit: Ideal candidates are people with opioid use disorder who present to EDs, EMS, or outpatient clinics—including those not doing well on office-based buprenorphine—and adolescents being followed after surgical opioid exposure when eligible.
Not a fit: People without opioid use disorder or those already stable and well controlled on their current medication are unlikely to benefit directly from these trials.
Why it matters
Potential benefit: If successful, the work could help more people stay connected to effective opioid treatment and reduce missed opportunities to start medication in emergency and prehospital settings.
How similar studies have performed: Prior research has shown ED-initiated buprenorphine and medications for opioid use disorder can work well, while EMS initiation and some pragmatic retention strategies are newer but promising approaches.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: D'onofrio, Gail — Yale University
- Study coordinator: D'onofrio, Gail
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.