New drugs to treat triple negative breast cancer using proteasome inhibitors

Who could benefit from this research

What this research studies

This research focuses on developing novel proteasome inhibitors that target specific subunits to improve treatment outcomes for patients with triple negative breast cancer. The approach aims to overcome resistance to existing proteasome inhibitors by simultaneously inhibiting two key components of the proteasome, which may enhance the effectiveness of the treatment. By understanding how these inhibitors affect tumor cells, the research seeks to provide a more effective therapy for patients who currently have limited options. The study will involve laboratory experiments and potentially clinical trials to evaluate the safety and efficacy of these new drugs.

Why it matters

Where this research is happening

• Weill Medical Coll of Cornell Univ
  New York, United States Active

Researchers

• Principal investigator: Lin, Gang — Weill Medical Coll of Cornell Univ
• Study coordinator: Lin, Gang

Related research

Other NIH-funded projects on the same topics.

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• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

  Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

  A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.

  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.