New Drug Combinations for Childhood Soft Tissue Sarcomas
In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas
This research looks for better drug combinations to treat soft tissue sarcomas in children, especially when the cancer returns.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11158801 on NIH RePORTER |
What this research studies
Our team is working to find new and more effective treatments for children with soft tissue sarcomas, a type of cancer where survival rates haven't improved much in a long time. We are especially focused on helping children whose cancer has come back, as their chances of survival are currently low. To do this, we use special models created from patient tumor samples to test many different drug combinations. Our goal is to discover new therapies that can improve both survival and the overall quality of life for these young patients.
Who could benefit from this research
Good fit: This research is focused on children aged 0-11 years old who have soft tissue sarcomas, particularly those with recurrent disease.
Not a fit: Patients with other types of cancer or adults with soft tissue sarcomas may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective drug treatments that improve survival rates and reduce side effects for children with soft tissue sarcomas.
How similar studies have performed: This approach builds on 10 years of experience developing patient-derived models and using them for drug screening, suggesting a well-established methodology.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Dyer, Michael a — St. Jude Children's Research Hospital
- Study coordinator: Dyer, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.