New DNA markers for early detection of lung cancer.
Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer.
This study is looking for a new, gentle way to help find out if lung nodules are cancerous or not by testing tiny bits of DNA in the blood, which could really help patients who have uncertain results from their CT scans.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10881929 on NIH RePORTER |
What this research studies
This research focuses on developing new, non-invasive DNA biomarkers to improve the early detection of non-small cell lung cancer (NSCLC). By analyzing ultra-short cell-free DNA found in the blood of patients, the study aims to differentiate between benign and malignant lung nodules detected through CT scans. The approach seeks to enhance the sensitivity of current diagnostic methods, which often struggle with high false positive rates. Patients with indeterminate pulmonary nodules may benefit from this innovative diagnostic tool.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been identified with indeterminate pulmonary nodules through low-dose CT scans.
Not a fit: Patients without lung nodules or those with confirmed lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of lung cancer, potentially saving lives.
How similar studies have performed: Previous research has shown promise in using liquid biopsies for cancer detection, suggesting that this approach may yield successful outcomes.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Li, Feng — University of California Los Angeles
- Study coordinator: Li, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.