New Dental Fillings to Stop Cavities from Coming Back
Official title: Microenvironmental characterization and manipulation to prevent secondary caries
Funded at Oregon State University · NIH-11184274 · Data updated 2026-11-12
This project is creating new dental filling materials designed to prevent cavities from forming again around existing fillings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project start | August 1, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $471,173 |
| NIH project number | 5R01DE027999-07 |
| Project ID | NIH-11184274 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for anyone who has dental fillings or is prone to developing cavities around their existing restorations.
✕Less likely to help
Patients who do not have dental fillings or do not experience recurrent cavities around their restorations may not directly benefit from this specific advancement.
What this research studies
Many people experience new cavities forming around their dental fillings, often due to bacteria in the mouth. Current treatments replace the old filling, but don't change the bacterial environment, leading to the same problem recurring. This research aims to develop innovative filling materials that release special ingredients like magnesium and zinc. These ingredients are intended to create a healthier environment in your mouth, making it harder for harmful bacteria to cause new cavities around your dental work.
Why it matters
Potential benefit: If successful, this could lead to dental fillings that last longer and significantly reduce the need for repeat cavity treatments.
How similar studies have gone: Preliminary data from this research team has shown that releasing magnesium and zinc from dental materials can support a healthier microbial environment.
Where this research is happening
-
Oregon State University
Corvallis, United States Active
Researchers
- Principal investigator: Koley, Dipankar — Oregon State University
- Study coordinator: Koley, Dipankar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.