New computer tools to find DNA and RNA changes using advanced sequencing
Novel bioinformatics methods to detect DNA and RNA modifications using Nanopore long-read sequencing
This project creates better computer programs to find tiny changes in DNA and RNA that are linked to human diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11142578 on NIH RePORTER |
What this research studies
Our bodies' DNA and RNA have small chemical changes that play a role in how our genes work and can contribute to various health conditions. Current ways to find these changes often miss important details or have technical issues. This project aims to develop new, highly accurate computer methods that use a special type of sequencing, called Nanopore long-read sequencing, to directly spot these DNA and RNA modifications. These new tools will help scientists get a clearer picture of these changes, even in complex parts of our genetic code, which could lead to a deeper understanding of diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on these methods could benefit individuals with diseases linked to DNA and RNA modifications.
Not a fit: Patients not affected by diseases related to DNA or RNA modifications would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could provide researchers with more precise tools to understand how DNA and RNA modifications contribute to human diseases, potentially leading to new ways to diagnose or treat these conditions.
How similar studies have performed: Previous work by this team has successfully developed computational tools for detecting DNA modifications using similar sequencing technology, indicating a strong foundation for this novel approach.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wang, Kai — Children's Hosp of Philadelphia
- Study coordinator: Wang, Kai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.