New coatings for dentures to prevent fungal infections
Salivary peptide/protein-based multilayer denture coatings for controlling Candida biofilm formation and denture stomatitis
['FUNDING_R01'] · UNIVERSITY OF MASSACHUSETTS LOWELL · NIH-11158935
This study is looking at new ways to coat dentures with natural proteins from saliva to help stop the growth of a fungus that can cause painful infections, especially for older adults who wear dentures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS LOWELL (nih funded) |
| Locations | 1 site (LOWELL, UNITED STATES) |
| Trial ID | NIH-11158935 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative coatings for dentures that utilize natural salivary proteins to prevent the growth of Candida, a fungus that can cause painful infections in denture wearers. The approach involves creating multilayer coatings on dentures that enhance the binding of these protective proteins, which have shown effectiveness against fungal biofilms. By using a layer-by-layer self-assembly technique, the researchers aim to improve the durability and effectiveness of these coatings, potentially reducing the incidence of denture stomatitis, especially in vulnerable populations such as the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals or those with compromised immune systems who wear dentures and are at risk for Candida infections.
Not a fit: Patients who do not wear dentures or those without any risk factors for Candida infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the occurrence of painful fungal infections in denture wearers, improving their oral health and quality of life.
How similar studies have performed: Previous research has shown promise in using salivary proteins for antifungal applications, indicating that this approach may lead to successful outcomes.
Where this research is happening
LOWELL, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS LOWELL — LOWELL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, YUYU — UNIVERSITY OF MASSACHUSETTS LOWELL
- Study coordinator: SUN, YUYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.