New catheters that release Nitric Oxide to prevent infections and blood clots
Official title: Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters
Funded at Nytricx INC. · NIH-11139086 · Data updated 2026-11-12
This study is testing new catheters that release a natural substance called Nitric Oxide to help prevent infections and blood clots, making them safer and more effective for patients who need them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nytricx INC. NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | May 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $121,338 |
| NIH project number | 3R42HL149595-03S1 |
| Project ID | NIH-11139086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require long-term catheterization for medical treatments.
✕Less likely to help
Patients who do not require catheterization or have contraindications for catheter use may not benefit from this research.
What this research studies
This research focuses on developing innovative intravascular catheters that release Nitric Oxide (NO), a natural substance that helps prevent infections and blood clots. The catheters are designed with a special polymer matrix that mimics the body's natural release of NO, targeting both the internal and external surfaces of the catheter. By doing so, the technology aims to reduce the risk of chronic infections and thrombosis, which are common complications associated with traditional catheters. Patients using these catheters may experience fewer complications and longer-lasting devices, improving their overall treatment experience.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of infections and blood clots in patients requiring intravascular catheters.
How similar studies have gone: Similar approaches using NO-releasing technologies have shown promise in other medical applications, indicating potential for success in this novel catheter design.
Where this research is happening
-
Nytricx INC.
Athens, United States Active
Researchers
- Principal investigator: Shebuski, Ronald J. — Nytricx INC.
- Study coordinator: Shebuski, Ronald J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.