New catheters that release nitric oxide to prevent infections and blood clots
Official title: Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters
Funded at Nytricx INC. · NIH-10929520 · Data updated 2026-11-12
This study is testing a new type of catheter that releases a natural substance to help prevent infections and blood clots, which could make life easier and safer for patients who need catheters for a long time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nytricx INC. NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | May 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $875,855 |
| NIH project number | 5R42HL149595-03 |
| Project ID | NIH-10929520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require long-term use of intravascular catheters for medical treatment.
✕Less likely to help
Patients who do not require catheterization or have contraindications for catheter use may not benefit from this research.
What this research studies
This research focuses on developing innovative intravascular catheters that release nitric oxide (NO), a natural substance in the body that helps prevent infections and blood clots. The catheters are designed with a special polymer that allows for the controlled release of NO, mimicking the body's natural defenses. By applying this technology, the goal is to enhance the safety and longevity of catheters used in medical settings, reducing the risk of complications such as chronic infections and thrombosis. Patients with indwelling catheters may benefit from this advancement, as it aims to improve their overall health outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of infections and blood clots in patients using intravascular catheters.
How similar studies have gone: Previous research has shown promising results with nitric oxide in medical applications, indicating potential success for this innovative approach.
Where this research is happening
-
Nytricx INC.
Athens, United States Active
Researchers
- Principal investigator: Shebuski, Ronald J. — Nytricx INC.
- Study coordinator: Shebuski, Ronald J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.