New catheter solutions to prevent infections and blood clots
Official title: Antibacterial and Antithrombotic Catheter Lock Solutions Based on Controlled Release of Nitric Oxide
Funded at Virginia Commonwealth University · NIH-11031973 · Data updated 2026-11-12
This study is exploring a new way to keep central venous catheters safe by using a special solution that releases nitric oxide to help prevent infections and blood clots, making it a friendly option for patients who need these catheters.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $388,125 |
| NIH project number | 5R01HL168133-03 |
| Project ID | NIH-11031973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients requiring central venous catheters for treatments such as hemodialysis, chemotherapy, or parenteral nutrition.
✕Less likely to help
Patients who do not require central venous catheters or those with contraindications to nitric oxide treatments may not benefit from this research.
What this research studies
This research investigates innovative catheter lock solutions that release nitric oxide to prevent infections and blood clots associated with central venous catheters. By using a natural compound called S-nitrosoglutathione, the study aims to create a safe and effective method to reduce the risk of complications without contributing to antibiotic resistance or causing adverse side effects. The release of nitric oxide can be precisely controlled to last from one day to over a month, tailored to different medical needs. This approach seeks to improve patient outcomes by minimizing the morbidity and mortality linked to catheter use.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of infections and blood clots for patients with central venous catheters.
How similar studies have gone: While the use of nitric oxide in medical applications is promising, this specific approach to catheter lock solutions is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Wang, Xuewei — Virginia Commonwealth University
- Study coordinator: Wang, Xuewei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.