New blood tests for early liver cancer detection in American Indian and Alaska Native patients
Novel biomarker strategies for HCC early detection in AI/AN patients
This study is working on a simple blood test to help find liver cancer early in American Indian and Alaska Native communities, where getting imaging tests can be tough, by looking for specific changes in the genes of people with liver cancer from these groups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10706313 on NIH RePORTER |
What this research studies
This research focuses on developing blood-based biomarker panels to detect hepatocellular carcinoma (HCC) early, particularly in American Indian and Alaska Native (AI/AN) communities that may lack access to imaging facilities. The study aims to identify unique genomic and epigenomic alterations in HCC patients from these populations, which may differ from those in predominantly Caucasian groups. By utilizing a translational approach, the research seeks to validate existing biomarker tests and adapt them for AI/AN patients, enhancing early detection and compliance with screening protocols.
Who could benefit from this research
Good fit: Ideal candidates for this research are American Indian and Alaska Native individuals at risk for hepatocellular carcinoma.
Not a fit: Patients who do not identify as American Indian or Alaska Native may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection of liver cancer in AI/AN patients, potentially saving lives through timely intervention.
How similar studies have performed: Previous studies have shown promise with blood-based biomarker tests for liver cancer, but this specific approach tailored for AI/AN populations is novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Grady, William Mallory — University of Washington
- Study coordinator: Grady, William Mallory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.