New Approaches for Healing Age-Related Skin Wounds
Multicomponent Therapy for Age-related Skin Stem Cell Deficiency
This research aims to find new ways to help older adults heal chronic skin wounds by understanding how aging affects skin stem cells.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11112451 on NIH RePORTER |
What this research studies
Many older adults experience chronic wounds that don't heal well, along with fragile skin and other signs of aging. This happens because skin stem cells, which are crucial for repair, don't work as well over time. Our team is working to understand exactly why these stem cells become less effective with age. By learning more about this process, we hope to develop new treatments that can improve wound healing and overall skin health for aging individuals.
Who could benefit from this research
Good fit: Ideal candidates for future related studies might be older adults experiencing chronic, non-healing skin ulcers or significant skin fragility.
Not a fit: Patients without age-related skin issues or chronic wounds are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help chronic wounds heal faster and improve skin strength for older adults.
How similar studies have performed: The basic biology of age-associated changes in wound healing is currently not well understood, indicating this approach is exploring new territory.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Frank, Markus H. — Brigham and Women's Hospital
- Study coordinator: Frank, Markus H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.