New approach to improve the success of arteriovenous fistulas for dialysis
Official title: Novel Molecular Target to Prevent Maturation Failure of Arteriovenous Fistula
Funded at Western University of Health Sciences · NIH-10457852 · Data updated 2026-11-12
This study is looking into why some arteriovenous fistulas (AVFs) don’t develop properly for dialysis and is testing new treatments that could help them mature better, which could be really helpful for patients who rely on dialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Western University of Health Sciences NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project start | August 1, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $704,979 |
| NIH project number | 5R01HL147662-04 |
| Project ID | NIH-10457852 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require hemodialysis and are at risk of arteriovenous fistula maturation failure.
✕Less likely to help
Patients who do not require hemodialysis or have alternative vascular access methods may not benefit from this research.
What this research studies
This research investigates the reasons behind the failure of arteriovenous fistulas (AVFs) to mature properly for use in hemodialysis. It focuses on the role of inflammation and specific proteins that contribute to the inadequate blood flow in these fistulas. By testing new treatments that block these proteins in animal models, the research aims to find ways to enhance the maturation of AVFs, making them more effective for patients needing dialysis.
Why it matters
Potential benefit: If successful, this research could lead to improved vascular access for patients undergoing hemodialysis, reducing complications and enhancing treatment efficacy.
How similar studies have gone: Other research has shown promise in targeting similar pathways to improve vascular access outcomes, suggesting that this approach could be effective.
Where this research is happening
-
Western University of Health Sciences
Pomona, United States Active
Researchers
- Principal investigator: Agrawal, Devendra K. — Western University of Health Sciences
- Study coordinator: Agrawal, Devendra K.
Related research
Other NIH-funded projects on the same topics.
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Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
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Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
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Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
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How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
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Improving AV fistula longevity by guiding vein remodeling
A research project is exploring how to help veins adapt better when used for hemodialysis access so patients have fewer costly procedures.
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Bioabsorbable wrap to improve AV fistula outcomes
A new bioabsorbable wrap is being studied to help AV fistula surgery heal better and stay open longer for people needing hemodialysis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.