New approach to improve the success of arteriovenous fistulas for dialysis
Novel Molecular Target to Prevent Maturation Failure of Arteriovenous Fistula
This study is looking into why some arteriovenous fistulas (AVFs) don’t develop properly for dialysis and is testing new treatments that could help them mature better, which could be really helpful for patients who rely on dialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Western University of Health Sciences NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project ID | NIH-10457852 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the failure of arteriovenous fistulas (AVFs) to mature properly for use in hemodialysis. It focuses on the role of inflammation and specific proteins that contribute to the inadequate blood flow in these fistulas. By testing new treatments that block these proteins in animal models, the research aims to find ways to enhance the maturation of AVFs, making them more effective for patients needing dialysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who require hemodialysis and are at risk of arteriovenous fistula maturation failure.
Not a fit: Patients who do not require hemodialysis or have alternative vascular access methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vascular access for patients undergoing hemodialysis, reducing complications and enhancing treatment efficacy.
How similar studies have performed: Other research has shown promise in targeting similar pathways to improve vascular access outcomes, suggesting that this approach could be effective.
Where this research is happening
Pomona, United States
- Western University of Health Sciences — Pomona, United States (Active)
Researchers
- Principal investigator: Agrawal, Devendra K. — Western University of Health Sciences
- Study coordinator: Agrawal, Devendra K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.