New antidotes for poisoning from certain insecticides
Official title: Novel oxime antidotes for an organophosphate insecticide requiring bioactivation
Funded at Mississippi State University · NIH-10913292 · Data updated 2026-11-12
This study is looking at new antidotes that can help people who have been poisoned by certain insecticides, aiming to improve their recovery by making a key enzyme work again.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $183,125 |
| NIH project number | 5R21NS131159-02 |
| Project ID | NIH-10913292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to organophosphate insecticides or nerve agents, particularly in acute poisoning scenarios.
✕Less likely to help
Patients who have not been exposed to organophosphate compounds or who are not experiencing acute poisoning symptoms may not benefit from this research.
What this research studies
This research focuses on developing novel oxime antidotes to counteract the effects of organophosphate insecticides, which can cause severe poisoning and neurological damage. The study investigates how these new antidotes can effectively reactivate acetylcholinesterase, an enzyme inhibited by these toxic compounds, and aims to improve treatment outcomes for individuals exposed to high doses. By exploring the timing and effectiveness of these antidotes, the research seeks to enhance patient safety and recovery from acute poisoning incidents.
Why it matters
Potential benefit: If successful, this research could provide more effective treatments for patients suffering from organophosphate poisoning, potentially reducing mortality and long-term neurological damage.
How similar studies have gone: Previous research has shown promise in developing antidotes for organophosphate poisoning, but this approach with novel oximes is relatively new and untested in clinical settings.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Meek, Edward C — Mississippi State University
- Study coordinator: Meek, Edward C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.