New antibiotics targeting resistant Gram-positive bacteria
Membrane-active quinoline and quinazoline antibacterials that target Gram positive pathogens
This study is looking for new medicines to help fight tough infections caused by bacteria like MRSA and Enterococcus, which don't respond well to regular treatments, so that patients with these infections can have better options for recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10767315 on NIH RePORTER |
What this research studies
This research focuses on developing new antibacterial agents specifically designed to combat resistant Gram-positive bacteria, such as MRSA and Enterococcus. The approach involves screening a large library of compounds to identify those with effective antibacterial properties. The researchers are synthesizing and testing various analogues of quinoline and quinazoline derivatives to enhance their efficacy and solubility. Patients with infections caused by these resistant bacteria may benefit from the new treatments that emerge from this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are patients suffering from infections caused by Gram-positive bacteria, particularly those that are resistant to current antibiotic treatments.
Not a fit: Patients with infections caused by Gram-negative bacteria or those not infected with any bacterial pathogens may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by resistant Gram-positive bacteria.
How similar studies have performed: Other research has shown promise in developing new antibiotics targeting resistant bacteria, indicating that this approach has potential for success.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Cheung, Ambrose Lin Yau — Dartmouth College
- Study coordinator: Cheung, Ambrose Lin Yau
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.