New anti-tubercular agents that work inside human cells to fight TB
Official title: Change of Recipient Organisation: New anti-tubercular agents targeting intracellular bacteria
Funded at Tmliverpool School of Tropical Medicine · NIH-11472547 · Data updated 2026-11-12
Aims to test new antibiotic compounds that can kill Mycobacterium tuberculosis inside human cells to shorten TB therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tmliverpool School of Tropical Medicine NIH-funded |
| Lab location | 1 site (Liverpool, United Kingdom) |
| Project start | June 21, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $493,309 |
| NIH project number | 7R01AI173110-03 |
| Project ID | NIH-11472547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with active or latent TB or those at risk of drug-resistant TB, depending on future clinical development.
✕Less likely to help
People not eligible for future trials or whose TB is not driven by intracellular intracellular bacteria may not benefit.
What this research studies
TB often survives inside immune cells, making it hard to treat. This project screens chemical series for activity against intracellular TB and chooses promising candidates for further study. Researchers will use cell-based assays to see if the compounds kill bacteria while keeping human cells healthy, and will try to uncover how these drugs work. The goal is to identify drugs that could shorten treatment for TB patients who harbor intracellular bacteria.
Why it matters
Potential benefit: If successful, patients could have shorter and more effective TB treatment options.
How similar studies have gone: Similar intracellular TB drug discovery approaches have identified promising compounds, but clinical efficacy remains to be demonstrated.
Where this research is happening
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Tmliverpool School of Tropical Medicine
Liverpool, United Kingdom Active
Researchers
- Principal investigator: Parish, Tanya — Tmliverpool School of Tropical Medicine
- Study coordinator: Parish, Tanya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.