Neutrophil elastase changes how immune cells function in cystic fibrosis.
The Trojan Horse Hypothesis: Neutrophil Elastase Reprograms Macrophage Function
This study is looking at how a protein called neutrophil elastase, which is found in high amounts in the lungs of people with cystic fibrosis, changes the way certain immune cells called macrophages work, and it hopes to find out how this might make lung problems worse for those with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10683401 on NIH RePORTER |
What this research studies
This research investigates how neutrophil elastase (NE), a protein found in high levels in the lungs of cystic fibrosis (CF) patients, affects the function of macrophages, which are crucial immune cells. The study aims to understand how NE alters macrophage behavior from protective to inflammatory, potentially worsening lung disease. Researchers will analyze macrophages derived from both healthy individuals and CF patients to explore the mechanisms by which NE influences immune responses. By examining the cellular processes involved, the research seeks to uncover new insights into the role of NE in CF and its impact on lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing lung inflammation.
Not a fit: Patients without cystic fibrosis or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve immune function and reduce inflammation in cystic fibrosis patients.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that targeting immune cell function can lead to significant improvements in managing inflammatory diseases.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Voynow, Judith a — Virginia Commonwealth University
- Study coordinator: Voynow, Judith a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.