Neurogranin's role in recovery after traumatic brain injury
Neurogranin and Traumatic Brain Injury
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11212815
Researchers are testing whether changing levels of the brain protein neurogranin can help protect memory, learning, and attention after traumatic brain injury in Veterans and others.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11212815 on ClinicalTrials.gov |
What this research studies
This project looks at how the synaptic protein neurogranin affects thinking and memory after traumatic brain injury using laboratory models that mimic TBI. Scientists use tools such as viral vectors to change neurogranin levels and then measure behavior, brain circuitry, and molecular signs of synaptic health. The work aims to identify whether restoring or protecting neurogranin-related signaling can prevent long-lasting cognitive problems. Findings would guide future treatments that could be tested in people with persistent problems after TBI.
Who could benefit from this research
Good fit: People with a history of traumatic brain injury who continue to have problems with memory, learning, or attention—particularly Veterans—would be the most relevant group for follow-up human research based on this work.
Not a fit: People without prior TBI or whose symptoms are unrelated to cognitive or memory problems are unlikely to benefit from the interventions studied here.
Why it matters
Potential benefit: If successful, this research could point to new therapies that protect or restore memory and attention after traumatic brain injury.
How similar studies have performed: Related lab studies targeting synaptic proteins have shown promising results in animal models, but translating those findings into proven human treatments remains unproven.
Where this research is happening
PITTSBURGH, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIXON, C EDWARD — VETERANS HEALTH ADMINISTRATION
- Study coordinator: DIXON, C EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease