Network to predict and track early psychosis risk
ProNET: Psychosis-Risk Outcomes Network
['FUNDING_U01'] · YALE UNIVERSITY · NIH-11382685
This project follows people at clinical high risk for psychosis and uses brain scans, EEG, genetics, blood tests, speech samples, and smartphone data to find patterns that predict clinical outcomes.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11382685 on ClinicalTrials.gov |
What this research studies
You would join a large international network that follows people at clinical high risk for psychosis over two years with eight check-ins. At visits you may have MRI and EEG scans, provide blood or other body-fluid samples, give brief speech tasks, complete cognitive and symptom measures, and use a phone app for real-time surveys and passive sensor data. The study will include about 1,040 high-risk participants and 260 healthy volunteers for comparison, with biomarker data collected at two timepoints to track brain–behavior change. The goal is to combine these different kinds of data to identify groups with shared outcome trajectories and potential treatment targets.
Who could benefit from this research
Good fit: Ideal candidates are people identified as clinical high risk for psychosis (for example, those with recent attenuated psychotic symptoms or functional decline).
Not a fit: People with an established psychotic disorder or conditions unrelated to early psychosis risk are unlikely to gain direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help predict who is most likely to develop psychosis and guide earlier, more personalized care.
How similar studies have performed: Prior smaller and single-site CHR biomarker studies have shown promising signals but inconsistent results, so this larger harmonized network is relatively novel and aimed at improving reliability.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOODS, SCOTT W — YALE UNIVERSITY
- Study coordinator: WOODS, SCOTT W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.