Network for rare and unusual forms of diabetes
RARE and Atypical Diabetes Network(RADIANT)
This project uses genetic tests, blood analyses, and patient-derived cell models to find causes of rare or atypical diabetes in people and their families.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11076257 on NIH RePORTER |
What this research studies
You would join a network that enrolls people whose diabetes does not fit typical type 1 or type 2 patterns and invites informative family members. The team collects detailed clinical information, blood samples for whole genome sequencing, RNA sequencing, and metabolomics, and may create patient-specific stem cell models to study how cells behave. All participants receive standardized clinical tests and specialized phenotyping so researchers can compare results across people. The goal is to discover distinct biological causes and better classify uncommon diabetes types to guide future care.
Who could benefit from this research
Good fit: Adults with diabetes that is hard to classify as type 1 or type 2—for example suspected monogenic (MODY), ketosis‑prone, brittle, or otherwise atypical diabetes—and willing family members are ideal candidates.
Not a fit: People with routine, clearly defined type 1 diabetes or obesity‑related type 2 diabetes with no atypical features are unlikely to benefit directly from this network.
Why it matters
Potential benefit: If successful, the work could lead to more accurate diagnoses and more personalized treatments for people with rare or atypical diabetes.
How similar studies have performed: Genetic studies have successfully identified specific monogenic diabetes forms before, but combining whole genome sequencing, metabolomics, transcriptomics, and patient‑derived cell models together is a relatively new and more comprehensive approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Balasubramanyam, Ashok — Baylor College of Medicine
- Study coordinator: Balasubramanyam, Ashok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.