Network for rare and atypical diabetes
RARE and Atypical Diabetes Network(RADIANT)
This project uses genome, blood, and other advanced tests to find causes and better treatments for people with rare or unusual forms of diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11376729 on NIH RePORTER |
What this research studies
If you join, clinicians will collect your medical history, perform a standardized physical exam, and take blood for whole genome sequencing, RNA sequencing, and metabolomics. They will measure insulin secretion, insulin sensitivity, antibodies, and other biomarkers to better classify your form of diabetes. The effort combines data from about 15 academic clinical sites with a central data coordinating center and sequencing/metabolomics cores. Results are used to find genetic causes, new disease subtypes, and to guide targeted therapies or future clinical trials.
Who could benefit from this research
Good fit: Adults whose diabetes does not fit typical type 1 or type 2 patterns—such as antibody-negative, brittle, adult-onset, or suspected monogenic diabetes—are ideal candidates.
Not a fit: People with routine, clearly defined type 2 diabetes driven by metabolic syndrome or well-controlled classic type 1 diabetes are less likely to gain direct benefit.
Why it matters
Potential benefit: If successful, this work could give people with atypical diabetes a more precise diagnosis and treatments tailored to the underlying cause.
How similar studies have performed: Genomic and 'omics studies in monogenic and unusual diabetes have previously identified actionable genetic causes and changed treatment for some patients, and RADIANT has already reported multiple candidate monogenic findings.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Balasubramanyam, Ashok — Baylor College of Medicine
- Study coordinator: Balasubramanyam, Ashok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.