Network for people at risk of psychosis
ProNET: Psychosis-Risk Outcomes Network
This project follows people with early warning signs of psychosis to collect brain scans, blood samples, symptom measures, and phone data to find markers that could help guide care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11382680 on NIH RePORTER |
What this research studies
You would join a large international network that follows people showing early or mild psychotic symptoms over two years with regular visits. The team collects many kinds of data, including MRI and EEG brain measures, genetics, blood and other body fluids, speech samples, cognitive testing, and passive smartphone sensor and survey data. About 1,040 at-risk participants across 26 sites will be seen at eight timepoints over 24 months, plus 260 healthy volunteers for comparison. Some brain and behavioral markers are measured at two timepoints to track change over time and link them to clinical outcomes.
Who could benefit from this research
Good fit: Ideal candidates are people who meet clinical high-risk criteria for psychosis or who have recent attenuated psychotic symptoms and can attend follow-up visits.
Not a fit: People without risk signs or those already diagnosed with a chronic or established psychotic disorder are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to better ways to predict who will develop psychosis and more personalized early treatments.
How similar studies have performed: Smaller studies of clinical high-risk groups have found promising markers, but this large, multi-site network and combined digital/biomarker approach is novel and larger than prior efforts.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.