Network for nonalcoholic steatohepatitis (NASH) and fatty liver disease
Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
This program is testing different vitamin E doses and collecting blood and tissue samples to better understand and help adults and children with nonalcoholic fatty liver disease (MASLD/NASH).
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11166517 on NIH RePORTER |
What this research studies
You would join a clinical network that follows adults and children with fatty liver over time and collects medical data and biological samples like blood and sometimes liver tissue. One part of the work is a vitamin E dose-finding trial to find a safe and helpful dose for metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will also analyze gene-expression data and measure features such as spleen stiffness to look for biomarkers that predict disease course. The network aims to keep strong follow-up and publish results that could guide future care.
Who could benefit from this research
Good fit: Adults and children diagnosed with nonalcoholic fatty liver disease (MASLD/NAFLD/NASH) who can attend clinic visits and provide blood and possibly tissue samples are ideal candidates.
Not a fit: People without fatty liver disease, those unable to attend regular follow-up visits, or those seeking an immediate cure rather than contributing to longer-term knowledge are unlikely to get direct benefit from participation.
Why it matters
Potential benefit: If successful, this work could identify better biomarkers and an effective vitamin E dose to guide treatment and monitoring for people with fatty liver disease.
How similar studies have performed: Previous NASH CRN work and trials like PIVENS have shown that vitamin E can help some patients and the network has produced validated biomarkers, so this project builds on established findings.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Sanyal, Arun J — Virginia Commonwealth University
- Study coordinator: Sanyal, Arun J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.