Network for myelofibrosis and related blood cancers
Myeloproliferative Neoplasms-Research Consortium
['FUNDING_P01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11094798
Doctors at multiple hospitals are testing new treatments to help people with myelofibrosis and related blood cancers live longer and feel better.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11094798 on ClinicalTrials.gov |
What this research studies
This consortium brings together laboratory and clinical teams at 13 centers to develop and run new treatment trials for myelofibrosis, polycythemia vera, and essential thrombocythemia. The focus is on therapies that go beyond first-generation JAK2 drugs by targeting the disease at the stem-cell level and seeking disease-modifying effects. Promising approaches move from lab studies into coordinated multi-center clinical trials so patients can access new options more quickly. Participants may be asked to provide blood or tissue samples and to attend clinic visits for treatment and follow-up.
Who could benefit from this research
Good fit: People diagnosed with myelofibrosis or other myeloproliferative neoplasms, particularly those who are not candidates for stem cell transplant or who have stopped JAK2 inhibitor therapy, are the intended candidates.
Not a fit: People without myeloproliferative neoplasms or those with unrelated medical conditions would not be eligible and are unlikely to benefit directly.
Why it matters
Potential benefit: Could produce better therapies that reduce symptoms, slow or reverse disease progression, and improve survival for patients with myelofibrosis and related disorders.
How similar studies have performed: First-generation JAK2 inhibitor trials have improved symptoms but not cured disease, and this consortium builds on that work to test newer, potentially disease-modifying strategies.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOFFMAN, RONALD — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: HOFFMAN, RONALD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.