Netrin-1 helps expand and improve human blood stem cells for better treatments.
Official title: Netrin-1 promotes the expansion and function of human hematopoietic stem cells by supporting a pro-hematopoietic vascular niche
Funded at University of Florida · NIH-11027115 · Data updated 2026-11-12
This study is looking at ways to grow more healthy blood stem cells to help patients with serious blood disorders recover faster and have fewer complications after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $295,438 |
| NIH project number | 1R01HL177599-01 |
| Project ID | NIH-11027115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with life-threatening blood disorders who may require hematopoietic stem cell transplantation.
✕Less likely to help
Patients with non-blood-related conditions or those who do not require stem cell transplantation may not benefit from this research.
What this research studies
This research focuses on enhancing the growth and function of human hematopoietic stem cells (HSCs), which are crucial for producing blood and immune cells. By creating a specialized environment that mimics the body's natural vascular niche, the study aims to significantly increase the number of available stem cells for transplantation. This could lead to improved recovery times and reduced complications for patients undergoing treatments for serious blood disorders. The approach has shown promise in earlier clinical trials, indicating its potential effectiveness.
Why it matters
Potential benefit: If successful, this research could provide patients with faster recovery from blood-related treatments and increase the availability of stem cell transplants.
How similar studies have gone: Previous research has successfully tested similar approaches in clinical trials, indicating a promising avenue for further exploration.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Butler, Jason Mathew — University of Florida
- Study coordinator: Butler, Jason Mathew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.