Nerve-signal and energy problems in Parkinson's disease
Synaptic Dysfunction and Energy Failure in Parkinson's Disease
This work looks at how energy shortages in brain cells and broken nerve connections may lead to symptoms in people with Parkinson's, especially those with LRRK2 gene changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11316979 on NIH RePORTER |
What this research studies
This project uses a mouse model that carries a common Parkinson's gene (LRRK2-R1441G) to study early changes in dopamine neuron connections and cellular energy. Researchers will track mitochondrial movement, respiration, ATP production, and oxidative stress with imaging (including 2-photon) and biochemical assays across different ages. They will compare mutant and normal mice to connect early synaptic and mitochondrial problems with later axon damage, tau changes, and motor symptoms. The goal is to reveal targets to protect neuron energy supply or synapses that could slow disease progression.
Who could benefit from this research
Good fit: People living with Parkinson's disease, particularly those with known LRRK2 mutations, are the population this research aims to benefit in the future.
Not a fit: Those whose Parkinson's is not related to LRRK2-linked mechanisms or whose disease is already far advanced may not see direct relevance from this specific work.
Why it matters
Potential benefit: If successful, this work could point to ways to protect neuronal energy production or synapses and slow or delay Parkinson's progression.
How similar studies have performed: Related studies using LRRK2 mouse models have reproduced Parkinson's-like features and shown mitochondrial problems, but directly targeting mitochondrial trafficking and synaptic energy failure is a newer approach.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Zhang, Hui — University of Georgia
- Study coordinator: Zhang, Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.