Nerve receptor that causes itch in eczema and allergic skin inflammation
Neuronal MRGPR signaling in itch and allergic skin inflammation
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11238041
The project tests whether a nerve receptor called MRGPRX2 drives itch and allergic skin inflammation in people with conditions like atopic dermatitis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11238041 on ClinicalTrials.gov |
What this research studies
Researchers are studying how skin nerves trigger itch and allergic inflammation through a receptor called MRGPRX2. They will use a new mouse model of skin inflammation, lab experiments on the human form of the receptor, and tests on nerve and immune cells. The team focuses on how the neuropeptide substance P activates this receptor to cause itching and immune reactions. If the receptor proves key, researchers will try blocking it in the lab to see whether itch and inflammation decrease.
Who could benefit from this research
Good fit: People with atopic dermatitis or other allergic eczematous skin conditions who experience chronic itch would be the most relevant candidates.
Not a fit: People without allergic or eczematous skin disease, or whose itch comes from unrelated causes, are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this research could point to new treatments that reduce itch and allergic inflammation in conditions like atopic dermatitis.
How similar studies have performed: Previous animal and laboratory studies suggest MRGPR family receptors interact with substance P and influence itch, so the approach is novel but supported by preclinical data.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LERNER, ETHAN A — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: LERNER, ETHAN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.