NDPP-NextGen: Reducing obesity and diabetes risks across generations
NDPP-NextGen: A clinical trial to reduce intergenerational obesity and diabetes risks
This project offers a lifestyle program to help young women before pregnancy, aiming to lower the chances of obesity and diabetes for both mothers and their future children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-11093407 on NIH RePORTER |
What this research studies
Many women start pregnancy with overweight, obesity, or diabetes, which can pass health risks to their babies, creating a cycle of disease across generations. While lifestyle programs during pregnancy exist, this project believes starting an intervention even earlier, before conception, could be more effective. We are adapting the National Diabetes Prevention Program (NDPP), a proven weight and blood sugar reduction program, for young women who plan to become pregnant. The goal is to improve health for mothers and their children from the very beginning.
Who could benefit from this research
Good fit: Ideal candidates are young women, especially those from racial and ethnic minority or low-income backgrounds, who are overweight or obese, at risk for diabetes, and planning to conceive soon.
Not a fit: Patients who are not of childbearing age, are not planning to conceive, or do not have overweight, obesity, or diabetes risk may not directly benefit from this specific program.
Why it matters
Potential benefit: If successful, this program could help break the cycle of obesity and diabetes, leading to healthier pregnancies and healthier children for generations to come.
How similar studies have performed: While prenatal lifestyle interventions are common, research on pre-conception interventions specifically targeting offspring outcomes is limited, making this a novel approach building on the established success of the NDPP for adults.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Sauder, Katherine a. — Wake Forest University Health Sciences
- Study coordinator: Sauder, Katherine a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.