NCOA7 deficiency and its effects on brain damage after stroke
Official title: NCOA7 deficiency worsens brain damage after stroke
Funded at Veterans Health Administration · NIH-11049616 · Data updated 2026-11-12
This study is looking at how a lack of the NCOA7 protein might affect brain damage after a stroke, and it aims to find out how this protein helps keep brain cells healthy, which could lead to new ways to help people recover from strokes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01BX006894-01 |
| Project ID | NIH-11049616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a stroke and may have genetic variations affecting NCOA7 expression.
✕Less likely to help
Patients who have not suffered a stroke or do not have relevant genetic factors related to NCOA7 may not benefit from this research.
What this research studies
This research investigates how a deficiency in the NCOA7 protein affects brain damage following a stroke. It focuses on understanding the role of NCOA7 in maintaining cellular health and its impact on the blood-brain barrier during ischemic events. By studying genetically modified mice and human stem cells, the research aims to uncover the mechanisms by which NCOA7 influences brain recovery after stroke. Patients may benefit from insights that could lead to new therapeutic strategies for stroke recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for stroke patients by targeting the mechanisms that worsen brain damage.
How similar studies have gone: Other research has shown promising results in understanding the role of genetic factors in stroke outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Sun, Dandan — Veterans Health Administration
- Study coordinator: Sun, Dandan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.