NCOA7 deficiency and its effects on brain damage after stroke
NCOA7 deficiency worsens brain damage after stroke
This study is looking at how a lack of the NCOA7 protein might affect brain damage after a stroke, and it aims to find out how this protein helps keep brain cells healthy, which could lead to new ways to help people recover from strokes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11049616 on NIH RePORTER |
What this research studies
This research investigates how a deficiency in the NCOA7 protein affects brain damage following a stroke. It focuses on understanding the role of NCOA7 in maintaining cellular health and its impact on the blood-brain barrier during ischemic events. By studying genetically modified mice and human stem cells, the research aims to uncover the mechanisms by which NCOA7 influences brain recovery after stroke. Patients may benefit from insights that could lead to new therapeutic strategies for stroke recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced a stroke and may have genetic variations affecting NCOA7 expression.
Not a fit: Patients who have not suffered a stroke or do not have relevant genetic factors related to NCOA7 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for stroke patients by targeting the mechanisms that worsen brain damage.
How similar studies have performed: Other research has shown promising results in understanding the role of genetic factors in stroke outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Sun, Dandan — Veterans Health Administration
- Study coordinator: Sun, Dandan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.