Nationwide network to bring treatments that target aging to people
Translational Geroscience Network
This national effort tests lifestyle changes, supplements, and medicines that target aging biology to help adults prevent or delay age-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11330785 on NIH RePORTER |
What this research studies
This national network brings together hospitals and researchers to move therapies that target the biology of aging from lab work into early human testing. It runs early-phase clinical trials and observational studies of lifestyle changes, supplements, and drugs (for example metformin, rapalogs, anti-inflammatories, senolytics, MitoQ, and NAD precursors). The network provides shared tools like lab assays, biobanking, data management, and help with study design and regulatory steps so trials can be run more quickly and reliably. By coordinating many small studies across different sites, the program aims to find which approaches improve resilience and delay multiple age-related problems.
Who could benefit from this research
Good fit: Ideal candidates are adults—especially older adults or people at risk for age-related conditions—who are willing to join early-phase trials or observational studies at participating clinical sites.
Not a fit: People seeking immediate cures for active severe illnesses, children, or those unwilling or unable to take experimental therapies are unlikely to benefit directly from these early-phase efforts.
Why it matters
Potential benefit: If successful, this work could help delay or prevent multiple age-related diseases and improve healthy lifespan for older adults.
How similar studies have performed: Early trials of some individual approaches like metformin, rapalogs, and senolytics have shown promising signals, but coordinating many geroscience interventions in a national network is a newer approach.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kirkland, James L. — Cedars-Sinai Medical Center
- Study coordinator: Kirkland, James L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.