N-glycosylation as a regulator of Grp94 function for disease care
Official title: N-glycosylation as a regulator of Grp94 Function and Activity
Funded at State University of New York at Buffalo · NIH-11406210 · Data updated 2026-11-12
A scientist is studying how sugar attachments to Grp94, a protein in the cell’s ER, change its job in helping cells manage stress and disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $322,000 |
| NIH project number | 5R01GM152842-04 |
| Project ID | NIH-11406210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for type 2 diabetes or cancer where Grp94-related pathways may be relevant.
✕Less likely to help
Individuals without Grp94-related disease pathways or those not participating in related clinical programs may not directly benefit.
What this research studies
Grp94 helps fold many proteins that end up on the cell surface or secreted, and its function may change when it has different glycosylation patterns. This project investigates how these sugar additions alter Grp94’s activity, with potential relevance to conditions like type 2 diabetes and certain cancers. The work involves biochemical analyses to see how glycosylation affects Grp94’s interactions and client maturation under stress. Findings could inform new ways to target Grp94 in therapy for chronic diseases and cancer.
Why it matters
Potential benefit: If successful, this research could identify new ways to modulate Grp94 to treat diabetes and cancer.
How similar studies have gone: Prior work suggests that Grp94 glycosylation changes its function, but the specific tuning mechanism is still being explored.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Gewirth, Daniel T — State University of New York at Buffalo
- Study coordinator: Gewirth, Daniel T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.