Myelofibrosis affects blood cell production through specific signaling pathways
Myelofibrosis impacts the hematopoietic niche through TNF-a
This study is looking at how myelofibrosis affects the bone marrow, which is important for making blood cells, and it aims to find new ways to help improve blood cell production and prevent serious issues like acute leukemia by understanding the signals that disrupt this process.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10887174 on NIH RePORTER |
What this research studies
This research investigates how myelofibrosis, a type of blood cancer, alters the environment in the bone marrow that is crucial for producing blood cells. The study focuses on understanding the role of tumor necrosis factor-alpha (TNF) and other signals that disrupt the normal function of bone marrow stromal cells, which support blood cell development. By analyzing patient samples, the research aims to identify new therapeutic targets that could help restore normal blood cell production and prevent complications like acute leukemia. The approach includes isolating and studying stromal cells to uncover the mechanisms behind these disruptions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with myelofibrosis or related myeloproliferative neoplasms.
Not a fit: Patients with other types of blood disorders that do not involve myelofibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood cell production and reduce the risk of severe complications in patients with myelofibrosis.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in myeloproliferative neoplasms, indicating potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Oetjen, Karolyn Ann — Washington University
- Study coordinator: Oetjen, Karolyn Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.