MYCN's role in creating a suppressive immune environment in neuroblastoma.
MYCN drives a suppressive tumor immune microenvironment in neuroblastoma.
['FUNDING_R21'] · BAYLOR COLLEGE OF MEDICINE · NIH-11114329
This study is looking at how a specific gene called MYCN affects the immune system in children with neuroblastoma, a type of cancer, to find new ways to help their bodies fight the disease better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11114329 on ClinicalTrials.gov |
What this research studies
This research investigates how the MYCN oncogene affects the immune environment in neuroblastoma, a type of cancer primarily affecting young children. It focuses on understanding the mechanisms by which MYCN alters T cell metabolism, leading to immune suppression that hinders effective treatment. The study aims to identify how MYCN creates a lipid-rich tumor microenvironment that not only supports tumor growth but also impairs the function of immune cells. By uncovering these processes, the research seeks to pave the way for new immunotherapy strategies that could improve outcomes for patients with high-risk neuroblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with high-risk neuroblastoma, particularly those with MYCN amplification.
Not a fit: Patients with low-risk neuroblastoma or those whose tumors do not exhibit MYCN amplification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for children with high-risk neuroblastoma.
How similar studies have performed: Other research has shown promise in targeting tumor microenvironments in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARBIERI, EVELINE — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: BARBIERI, EVELINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell metabolism, Cancer Genes, cancer in a child