Multiple brain imaging methods to detect early Alzheimer's changes in a mouse model
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's disease
They use different brain imaging tools in mice to find the earliest Alzheimer's-related changes so future tests and treatments can help people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10795753 on NIH RePORTER |
What this research studies
This project combines PET, wide-field calcium imaging, and BOLD fMRI in a genetically modified mouse that mimics Alzheimer's to trace changes from single synapses up to whole-brain networks. Imaging is performed at stages that mirror early disease and is paired with behavior tests to link brain changes to memory and function. The team aligns data across methods to understand how synapse loss leads to circuit and network dysfunction and includes both sexes. Findings are intended to reveal early signs and mechanisms that could guide preventative treatments.
Who could benefit from this research
Good fit: This is preclinical research in mice, so patients cannot enroll, though the results aim to benefit people at risk for Alzheimer's disease.
Not a fit: People with advanced Alzheimer's are unlikely to see direct benefit from this mouse-focused imaging research.
Why it matters
Potential benefit: If successful, this work could point to earlier, more precise markers of Alzheimer's and inform therapies that protect synapses and brain circuits.
How similar studies have performed: Separate PET and fMRI studies have shown related changes, but the fully aligned multimodal approach spanning synapses, circuits, and whole-brain networks is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Toyonaga, Takuya — Yale University
- Study coordinator: Toyonaga, Takuya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.