Multi‑Ethnic Alzheimer’s Genetics in African American and Hispanic/Latinx Populations
Project 2: Multi-Ethnic Analysis for Alzheimer Disease
Looking at genetic differences in African American and Hispanic/Latinx people to better understand who is at higher risk for Alzheimer’s.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11126021 on NIH RePORTER |
What this research studies
If you join, your DNA and health information will be added to a larger effort that includes African American, Hispanic/Latinx, European, and African ancestry groups. Researchers will use admixture mapping and trans‑ethnic genetic analyses to find gene variants that may raise or lower Alzheimer’s risk in different ancestries. They will compare chromosome segments inherited from different ancestral populations to identify ancestry‑linked risk or protective factors and also look for genetic signals shared across groups. The goal is to explain ancestry‑related differences in Alzheimer’s rates and point to tests or treatments that could work better for diverse communities.
Who could benefit from this research
Good fit: Adults of African, African American, or Hispanic/Latinx ancestry, including those with Alzheimer’s, mild cognitive impairment, or a family history who can consent and provide a DNA sample and health information.
Not a fit: People who are not part of the targeted ancestry groups or who cannot or will not provide genetic samples are unlikely to receive direct benefits from this project.
Why it matters
Potential benefit: Could improve risk prediction and lead to more ancestry‑informed prevention or treatment strategies for people from African and Hispanic/Latinx backgrounds.
How similar studies have performed: Many genetic discoveries for Alzheimer’s came from European groups, but applying admixture and trans‑ethnic methods to African American and Hispanic/Latinx populations is relatively new and may reveal novel findings.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Tosto, Giuseppe — University of Miami School of Medicine
- Study coordinator: Tosto, Giuseppe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.